Dose-finding design for multi-drug combinations
نویسندگان
چکیده
منابع مشابه
Bayesian dose finding in oncology for drug combinations by copula regression
Treating patients with a combination of agents is becoming commonplace in cancer clinical trials, with biochemical synergism often the primary focus. In a typical drug combination trial, the toxicity profile of each individual drug has already been thoroughly studied in singleagent trials, which naturally offers rich prior information.We propose a Bayesian adaptive design for dose finding that ...
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Two-agent combination trials have recently attracted enormous attention in oncology research. There are several strong motivations for combining different agents in a treatment: to induce the synergistic treatment effect, to increase the dose intensity with nonoverlapping toxicities, and to target different tumor cell susceptibilities. To accommodate this growing trend in clinical trials, we pr...
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ژورنال
عنوان ژورنال: Clinical Trials
سال: 2011
ISSN: 1740-7745,1740-7753
DOI: 10.1177/1740774511408748